Cimetidine Increases Drug Concentrations
July 17, 2008 – 12:27 pm
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The combined administration of cimetidine and mebendazole to patients with hydatid cysts has been reported to result in greater serum concentrations and therapeutic effects of mebendazole than when mebendazole was used alone. In addition, a recent report on the use of cimetidine in combination with albendazole for the treatment of cystic echinococcosis also found that concentrations and therapeutic effects of albendazole were significantly higher in patients receiving combination therapy than in those receiving albendazole alone.
Simultaneous administration of praziquantel and a benzimidazole has been suggested as a simple and cheap means of delivering treatment against all 3 major geohelminths and the schistosomes.
Results from a multi-center, double-blind trial have shown that the efficacy of concomitant albendazole and praziquantel therapy was indistinguishable from the efficacy of each drug alone, and that the frequency and severity of adverse effects were also unaffected.